Intrauterine Insemination (IUI)
In Vitro Fertilization (IVF) Fertility Treatments
Intrauterine insemination (IUI) and in vitro fertilization (IVF) are two of the most popular infertility treatments. Understanding these treatments and differences are a great place to begin your conversations with a fertility expert. Eden fertility centers offer advanced infertility treatment such as IUI & IVF in Newport Beach & Fullerton CA. We use high-tech approach & have extensive clinical experience treating infertility and achieving pregnancy.
- Complexity. IUI refers to a single procedure where sperm is placed directly in the patient’s uterus when she is ovulating. IUI may be performed in sync with a woman’s natural cycle or timed with fertility medications to stimulate ovulation. The IVF process consists of several stages and requires more than one procedure: first the ovaries are stimulated using a series of fertility medications; second, the patient undergoes egg retrieval in a day procedure under a mild anesthetic; third, the embryos are created and incubated in the lab, and then the embryo transfer into the patient’s uterus.
- Risk of multiples. IUI with fertility medication carries a significant risk of multiple pregnancies, while recent advances in IVF mean that most modern fertility clinics now transfer only one or two embryos per IVF cycle, lowering the risk of multiple pregnancies.
- Success rates. Statistically, IUI has lower success rates than IVF, and the gap widens as women age.
- IUI with fertility medication: average success rates range from 8-15 percent per cycle for patients under 35.
- IVF using a woman’s own eggs: average success rates range from 40-45 percent for patients under 35.
- Time involved. IUI is a much shorter process than IVF, so if your first cycle is successful, it could be the quickest route to pregnancy. But because of the gap in success rates, some patients in their late 30s to early 40s may get pregnant faster by going directly to IVF rather than waiting until they have had several failed IUI cycles.
- Treatment Cost. An IUI cycle costs much less than an IVF cycle, and may be the deciding factor for many patients. However, depending on your diagnosis and your chances of conceiving through IUI, it may be more cost-effective to go directly to an IVF cycle rather than dealing with multiple failed IUI cycles before ultimately proceeding to IVF.
Who are the best candidates for IUI?
- has at least one unblocked fallopian tube
- is able to ovulate, perhaps with the help of fertility medication
- has a healthy ovarian reserve (which means a good amount of healthy eggs)
- has a normal uterine cavity
When does it make sense to go straight to IVF?
The process of fertilizing an egg outside of the body using the most advanced expertise in assisted reproductive technologies. After IVF, the embryo is transferred into the uterus in order to establish pregnancy. This can occur as a fresh embryo transfer or as a frozen embryo transfer.
There are times when a patient is likely to have better results by skipping over the IUI option and beginning their fertility treatment with IVF. This is a choice each patient will have to make in consultation with their fertility specialist. IVF can be a better option for patients who:
- are over the age of 38
- have blocked fallopian tubes
- have reduced ovarian reserve
- decide to use donor eggs
- suffer from advanced endometriosis
- when a gestational carrier is needed
- are dealing with severe male infertility which may require the use of advanced technologies such as intracytoplasmic sperm injection (ICSI), testicular sperm extraction (TESL), or microsurgical epididymal sperm aspiration (MESA).
- may require genetic screening
Mini and Natural Cycle IVF
Natural cycle IVF offers patients the IVF process with fewer medications, fewer side effects and lower costs. There are generally three groups of women who are good candidates for natural cycle IVF:
- For women considered “poor responders,” natural cycle IVF affords the opportunity to continue with the IVF process, even when ovarian stimulation has repetitively failed to produce multiple embryos.
- For couples with infertility due to male factor (low or poor quality sperm), natural cycle IVF can provide an opportunity for fertilization through ICSI and at the same time avoid multiple pregnancies and unnecessary stimulation for an otherwise fertile female partner.
- Women who cannot tolerate or do not desire to take hormonal therapy in order to conceive can still benefit from the IVF process.
Minimal or Mild IVF
With minimal stimulation IVF low doses of hormones are used to obtain a small number of eggs while avoiding premature ovulation. Mild IVF helps avoid ovarian hyperstimulation, by limiting the production of eggs and swelling of the ovaries.
Minimal stimulation IVF protocols have gained popularity in recent years in many parts of the world, especially in Japan. These protocols produce slightly lower pregnancy chances per cycle than conventional stimulation IVF. However, this approach works well for women with very low ovarian reserve who do not produce large number of eggs on higher doses of fertility medications and women with poor egg quality in prior cycles. Mild IVF is a good option because it is much simpler and less expensive, allowing the patient to undergo several attempts at IVF. Most important is that live birth rates over several cycles add up to match and, in some cases, even surpass those achieved in a single conventional stimulation IVF cycle.
Women with history of ovarian hyperstimulation syndrome and those with PCOS are also potential candidates for mild IVF.
- Low or Diminished Ovarian Reserve
- Prior Ovarian Hyperstimulation Syndrome (OHSS)
- Polycystic Ovary Syndrome (PCOS)
- Want to avoid producing excess eggs or embryos for religious reasons
- Lower cost than conventional stimulation IVF
Benefits and Outcomes
Since small numbers of eggs are retrieved, most women can undergo these procedures with sedation only, thus reducing the cost and risk of anesthesia. In addition, since the egg numbers are low, a thinner needle is used for retrievals, thus decreasing the incidence of post-procedure internal bleeding—a rare complication of conventional IVF.
It’s important to remember that lower pregnancy rates are expected and more retrieval failures are seen since fewer embryos are transferred and the patients themselves usually have a poor prognosis by conventional standards.
What to Expect on Your First Visit
During your first consultation, a thorough examination will be carried out to determine the potential causes of your infertility. For the basic assessment, you and your partner will have to pass certain tests which will allow the doctor to make a diagnosis in your case and to offer you the treatment options most suited to your situation.
For Women: At the first visit, the doctor will review your medical history, including any previous tests or treatments you may have had for infertility. Your doctor may also want to do a pelvic examination. Your partner is also welcome to come to this visit, to make you as comfortable as possible.
Your doctor may require more information from you:
to chart your body temperature (basal body temperature) during your menstrual cycle to see if you are ovulating,
or he may recommend that you buy an ovulation predictor kit.
Sometimes, blood tests, ultrasound or X-ray tests, or surgical procedures are also recommended.
For Men: A brief health history will be taken at the initial evaluation. A semen analysis is essential in the course of an infertility evaluation for male infertility. Performed in the laboratory, the examination consists of collecting sperm and analyzing it.
Improves Your Chances of Conceiving
Ovulation induction is a term used to describe the use of oral or injectable fertility drugs used to stimulate the production of mature eggs by the ovaries. Ovulation induction aims to cause the development and ovulation of one or more eggs in a woman who does not normally ovulate. Depending on your diagnosis, your doctor will prescribe the treatment that is best for you.Ovulation induction is indicated in the following cases:
You have ovulation problems that have not responded to commonly prescribed medications.
You have unexplained infertility and want to try ovulation induction to increase the number of eggs produced during each cycle. With higher egg production, the chances of conception also increase.
To be able to benefit from an induction of ovulation, you must have a normal uterine cavity as well as at least one normal fallopian tube and your partner must have a normal number of sperm.
During natural fertilization, sperm are deposited at the cervix during ejaculation. They pass through the cervix, going up towards the body of the uterus and the fallopian tubes to fertilize the ovum in the fallopian tube. The fetus (baby) is therefore made in the fallopian tube and it descends to implant itself in the uterus after a few days.
For a couple, intrauterine insemination (IUI) consists of the injection into the uterus, by the gynecologist, of the partner’s sperm. This sperm is obtained by masturbation and must undergo laboratory treatment in order to be made fertile. The injection of sperm must, of course, be done exactly at the time of ovulation in women. This ovulation is determined by the gynecologist via ultrasounds and repeated blood tests.
Your doctor will tell you the best time to give this injection, as well as the time of insemination. Your doctor will tell you if you can also have sex.
In Vitro Fertilization (IVF)
By definition, artificial insemination deposits sperm in a woman’s uterus. In vitro fertilization (IVF) goes beyond this procedure by fertilizing a woman’s ovum with the man’s sperm outside the woman’s body. The term “test tube babies” is a synonym for IVF.
For most people, IVF simply involves joining two gametes in a test tube. But for couples who have decided to undergo IVF treatment, this process results in countless clinic appointments, blood tests and injections, as well as constant questions and encouragement and a lot of waiting. Waiting for test results, waiting for embryos, waiting for the pregnancy test, waiting for the birth of a child. Couples undergoing IVF treatment face several challenges, including learning all about the procedure, which includes a mass of information to assimilate which is not always easy to understand.
Before you decide to follow the treatment, we suggest that you learn as much as possible about IVF treatment by consulting your doctor and researching it using the many books and websites that exist on the subject. By being well informed about everything involved in the procedure, you will have more peace of mind when you start your IVF treatment.
Starting an LGBTQ Family
Welcoming a child is one of the greatest joys of life, and each experience is unique. Procreation, for the LGBTQ community, can represent its share of challenges. At Eden Fertility Centers, we are dedicated to supporting you and guiding you through all the concerns.
Here at Eden Fertility Centers, we are aware of the challenges, specific situations, and choices that gay parents have to face. It is with this in mind that we have developed specific protocols and recognized programs in order to satisfy the needs or preferences that you may have, as well as approaches that allow two men to become biological parents.
Our team of dedicated professionals is experienced in supporting patients with care and empathy in these treatment processes. Our expert embryologists, genetic counselors, nurses and psychotherapists are all on hand to guide you on your journey towards parenthood.
Elective Single Embryo Transfer (eSET)
Elective single-embryo transfer (eSET) is a procedure in which one embryo, selected from a larger number of available embryos, is placed in the uterus.
The embryo selected for eSET might be from a previous IVF cycle from the current fresh IVF cycle that yielded more than one embryo.
eSET helps women avoid complications that are associated with carrying multiples, including high blood pressure, high blood sugar, increased nausea and vomiting, other gastrointestinal problems, and problems with bleeding after delivery.
It also helps families achieve success while preventing some risks known to be associated with giving birth to twins or what is called “high order multiple births” (three or more children born at the same time). Infants born in multiple births are more often born early are smaller (low birth weight) and experience more adverse health outcomes than singleton infants.
Eden – The Future of Fertility
Eden Centers for Advanced Fertility is a patient-focused fertility clinic in Newport Beach and Fullerton, California. With years of experience, we offer our patients with myriad of treatment options including – third party reproduction, egg freezing, genetic testing, male infertility, while offering patient care.
Owing to our years of expertise, state of the art technology, competent team, Eden is a unanimous choice for the patients. We offer a friendly and accepting environment for our patients including LGTBQ+ community.