Intrauterine Insemination (IUI)
In Vitro Fertilization (IVF) Fertility Treatments
Intrauterine insemination (IUI) and in vitro fertilization (IVF) are two of the most popular infertility treatments. Understanding these treatments and differences are a great place to begin your conversations with a fertility expert. Eden fertility centers offer advanced infertility treatment such as IUI & IVF in Newport Beach & Fullerton CA. We use high-tech approach & have extensive clinical experience treating infertility and achieving pregnancy.
- Complexity. IUI refers to a single procedure where sperm is placed directly in the patient’s uterus when she is ovulating. IUI may be performed in sync with a woman’s natural cycle or timed with fertility medications to stimulate ovulation. The IVF process consists of several stages and requires more than one procedure: first the ovaries are stimulated using a series of fertility medications; second, the patient undergoes egg retrieval in a day procedure under a mild anesthetic; third, the embryos are created and incubated in the lab, and then the embryo transfer into the patient’s uterus.
- Risk of multiples. IUI with fertility medication carries a significant risk of multiple pregnancies, while recent advances in IVF mean that most modern fertility clinics now transfer only one or two embryos per IVF cycle, lowering the risk of multiple pregnancies.
- Success rates. Statistically, IUI has lower success rates than IVF, and the gap widens as women age.
- IUI with fertility medication: average success rates range from 8-15 percent per cycle for patients under 35.
- IVF using a woman’s own eggs: average success rates range from 40-45 percent for patients under 35.
- Time involved. IUI is a much shorter process than IVF, so if your first cycle is successful, it could be the quickest route to pregnancy. But because of the gap in success rates, some patients in their late 30s to early 40s may get pregnant faster by going directly for IVF treatment rather than waiting until they have had several failed IUI cycles.
- Treatment Cost. An IUI cycle costs much less than an IVF cycle, and may be the deciding factor for many patients. However, depending on your diagnosis and your chances of conceiving through IUI, it may be more cost-effective to go directly to an IVF cycle rather than dealing with multiple failed IUI cycles before ultimately proceeding to IVF.
Who are the best candidates for IUI?
- has at least one unblocked fallopian tube
- is able to ovulate, perhaps with the help of fertility medication
- has a healthy ovarian reserve (which means a good amount of healthy eggs)
- has a normal uterine cavity
When does it make sense to go straight to IVF?
The process of fertilizing an egg outside of the body using the most advanced expertise in assisted reproductive technologies. After IVF, the embryo is transferred into the uterus in order to establish pregnancy. This can occur as a fresh embryo transfer or as a frozen embryo transfer.
There are times when a patient is likely to have better results by skipping over the IUI option and beginning their fertility treatment with IVF in Orange County. This is a choice each patient will have to make in consultation with their fertility specialist. IVF can be a better option for patients who:
- are over the age of 38
- have blocked fallopian tubes
- have reduced ovarian reserve
- decide to use donor eggs
- suffer from advanced endometriosis
- when a gestational carrier is needed
- are dealing with severe male infertility which may require the use of advanced technologies such as intracytoplasmic sperm injection (ICSI), testicular sperm extraction (TESL), or microsurgical epididymal sperm aspiration (MESA).
- may require genetic screening
Mini and Natural Cycle IVF
Natural cycle IVF offers patients the IVF process with fewer medications, fewer side effects and lower costs. There are generally three groups of women who are good candidates for natural cycle IVF:
- For women considered “poor responders,” natural cycle IVF affords the opportunity to continue with the IVF process, even when ovarian stimulation has repetitively failed to produce multiple embryos.
- For couples with infertility due to male factor (low or poor quality sperm), natural cycle IVF can provide an opportunity for fertilization through ICSI and at the same time avoid multiple pregnancies and unnecessary stimulation for an otherwise fertile female partner.
- Women who cannot tolerate or do not desire to take hormonal therapy in order to conceive can still benefit from the IVF process.
Minimal or Mild IVF
With minimal stimulation IVF low doses of hormones are used to obtain a small number of eggs while avoiding premature ovulation. Mild IVF helps avoid ovarian hyperstimulation, by limiting the production of eggs and swelling of the ovaries.
Minimal stimulation IVF protocols have gained popularity in recent years in many parts of the world, especially in Japan. These protocols produce slightly lower pregnancy chances per cycle than conventional stimulation IVF. However, this approach works well for women with very low ovarian reserve who do not produce large number of eggs on higher doses of fertility medications and women with poor egg quality in prior cycles. Mild IVF is a good option because it is much simpler and less expensive, allowing the patient to undergo several attempts at IVF. Most important is that live birth rates over several cycles add up to match and, in some cases, even surpass those achieved in a single conventional stimulation IVF cycle.
Women with history of ovarian hyperstimulation syndrome and those with PCOS are also potential candidates for mild IVF.
- Low or Diminished Ovarian Reserve
- Prior Ovarian Hyperstimulation Syndrome (OHSS)
- Polycystic Ovary Syndrome (PCOS)
- Want to avoid producing excess eggs or embryos for religious reasons
- Lower cost than conventional stimulation IVF
Benefits and Outcomes
Since small numbers of eggs are retrieved, most women can undergo these procedures with sedation only, thus reducing the cost and risk of anesthesia. In addition, since the egg numbers are low, a thinner needle is used for retrievals, thus decreasing the incidence of post-procedure internal bleeding—a rare complication of conventional IVF.
It’s important to remember that lower pregnancy rates are expected and more retrieval failures are seen since fewer embryos are transferred and the patients themselves usually have a poor prognosis by conventional standards.
Elective Single Embryo Transfer (eSET)
Elective single-embryo transfer (eSET) is a procedure in which one embryo, selected from a larger number of available embryos, is placed in the uterus.
The embryo selected for eSET might be from a previous IVF cycle from the current fresh IVF cycle that yielded more than one embryo.
eSET helps women avoid complications that are associated with carrying multiples, including high blood pressure, high blood sugar, increased nausea and vomiting, other gastrointestinal problems, and problems with bleeding after delivery.
It also helps families achieve success while preventing some risks known to be associated with giving birth to twins or what is called “high order multiple births” (three or more children born at the same time). Infants born in multiple births are more often born early are smaller (low birth weight) and experience more adverse health outcomes than singleton infants.
Eden – The Future of Fertility
Eden Centers for Advanced Fertility is a patient-focused fertility clinic in Newport Beach and Fullerton, California. With years of experience, we offer our patients with myriad of treatment options including –IUI treatment, IVF treatment, third party reproduction, egg freezing, genetic testing, male infertility.
Owing to our years of expertise, state of the art technology, competent team, Eden is a unanimous choice for the patients. We offer a friendly and accepting environment for our patients including LGTBQ+ community.